It is an OK app, and performs quite nicely once it starts running. The problem with big libraries is that it takes ages to compare library data to Flickr data, and it makes resuming upload a big pain in the neck. Also, when you pause upload and want to resume it, you will have to reselect the library, and the workflow seems a bit buggy - hopefully an update to the app would fix this issue.
Zejusz about Backup to Flickr for iPhoto